Jindriska comes from Czech Republic, where she obtained her undergraduate degree in Applied Biochemistry at Masaryk University. She continued with her studies at the same university and got her master’s degree in Analytical Biochemistry. While studying, she worked in laboratory of Dr. Michal Masařík, where she assessed biological effects of newly synthesized anti-cancer agents, especially their anti-migratory activity. In 2019, she spent six months as an intern at the Centre de Recherche en cancérologie de Marseille, France. There she worked on the characterisation of perinuclear actin-septin network and its role in cell migration. After this experience she decided to continue in her studies abroad and decided to pursue her PhD in the Cilia Group, University of Copenhagen under supervision of Dr. Søren Tvorup Christensen.

Abstract
TGFβ/BMP signaling controls a complex network of spatiotemporal signaling pathways, which when dysregulated are major causes of developmental disorders and cancer. This signaling is coordinated by primary cilia and that activation of downstream signaling pathways is coupled to intraciliary trafficking as well as internalization and recycling of receptors at the ciliary base. However, the mechanisms underlying these trafficking events are largely unknown. ESR5 will decipher the molecular mechanisms by which primary cilia balance the output of diverse TGFβ/BMP pathways to control cellular and developmental processes using high resolution fluorescence microscopy and live cell imaging of cultures of wild type and CRISPR/Cas9-generated knockout cells. She will study the role of protein RRP7A, which has been shown to locate at the ciliary base and cells with mutated RRP7A display hyperactivated TGFβ signaling whereas BMP signaling is repressed. Proteomics/data analyses will be done in collaboration with P7-EKUT/P10-CellNetworks, respectively. In collaboration with ESR12, she will translate how ciliary trafficking events control developmental processes guided by TGFβ/BMP signaling in zebrafish.